Viagra History

by admin on March 4, 2012

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Viagra History: Discovery Timeline

1989

  • Pfizer Scientists synthesize silendafil citrate and give it the code name UK-92, 480. The drug would not be known as Viagra until the mid-90s.
  • Experimental compound UK-92,480 is believed to be useful as a high blood pressure and angina treatment. The scientists hope it may act as a vasodilator and be useful in treating cardiovascular ailments such as hypertension and angina.

1991

  • Researchers at Pfizer’s Sandwich, England research facility (Peter Ellis and Nick Terret) observe that drugs that inhibit the PDE5 enzyme may be helpful in reversing erectile dysfunction.
  • Early Phase 1 trials regarding the use of Viagra for angina are unremarkable.

1992

  • A second Phase 1 angina trial reveals that the drug has an unusual side effect; penile erections.
  • Phase 2 clinical study is conducted testing silendafil citrate’s usefulness as an angina treatment.

1993

  • Pilot study using silendafil citrate as a treatment for erectile dysfunction is conducted in Bristol, England. Test subjects take it three times a day for a week. The studies had only 28 men involved.

1994

  • Second pilot study on silendafil as an Erectile dysfunction treatment demonstrates that a once per day dose is able to produce an erection.
  • Pfizer realizes it has something important; it accelerates the program examining silendafil citrate for erectile dysfunction.

1994 – 1997

  • 21 clinical trials are conducted involving 4,500 men demonstrate that Viagra (as it is now known) is safe and effective.

1997

  • Pfizer files a New Drug Application for Viagra (NDA 020895) with the United States FDA. FDA agrees to give it a priority review.

1998

  • FDA approves Viagra as the first oral treatment for erectile dysfunction. It was approved with a starting dose of 50 mg with the option to increase the dose to 100mg or reduce it to 25 mg.

Misc:

  • FDA lists two patents for Viagra. Patent number 5250534 expires on March 27, 2012. Patent number 6469012 (patent use code U-155; TREATMENT OF ERECTILE DYSFUNCTION) is set to expire on Oct 22, 2019.

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How Much Does Viagra Cost… The Price of Viagra…

Authentic, FDA-approved Viagra does cost at least $20 per pill. So if you see websites where the cost of Viagra is $3, $5, or even $10 a pill, you will know that they are generic. Stay away from generic Viagra, as the pills are made from compounds that are not FDA-approved and can cause serious harm to your health. The cost of Viagra online should be about the same as you would get at your local pharmacy, but you can actually save money if you buy Viagra online because you won’t have a co-pay like you would if you received a Viagra prescription from your local doctor.

There is no such thing as an FDA approved generic Viagra.

The government considers generic Viagra to be an illegal substance.

The Feds are concerned that generic Viagra may be unsafe because you have no way of determining the quality control that went into making the generic Viagra. They don’t go after the people who buy it, but postal inspectors will confiscate it if they find it.

There are lots of websites that sell generic Viagra without a prescription. Your Viagra cost will be less if it is generic, but you are taking a chance with your health if you take generic sildenafil because the ingredients are completely unknown. If you are unsure where to buy Viagra, see my recommendation above.

 

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